Folding of polypeptide chains in proteins: a proposed mechanism for folding.
نویسندگان
چکیده
A mechanism is proposed for the folding of protein chains. On the basis of short-range interactions, certain aminoacid sequences have a high propensity to be, say, alpha-helical. However, these short helical (or other ordered) regions can be stabilized only by long-range interactions arising from the proximity of two such ordered regions. These regions are brought near each other by the directing influence of certain other aminoacid sequences that have a high probability of forming beta-bends or variants thereof, also on the basis of short-range interactions. An analysis is made of the tendency of various amino acids to occur in beta-bends, and it is possible to predict the regions of a chain in which a beta-bend will occur with a high degree of reliability.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 68 9 شماره
صفحات -
تاریخ انتشار 1971